The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but not limited to stroke, myocardial infarction, kidney failure. Platelet-activating factor (PAF) is a proinflammatory mediator synthesized from subclass of phosphatidylcholines increases platelet activation, leukocyte adhesion, infiltration macrophages, intracellular lipid accumulation, thereby contributing atherosclerosis. Magnesium, key micronutrient free radical scavenger, water-soluble mineral regulates peripheral vasodilation calcium, phosphate, hydroxyapatite homeostasis. Magnesium’s antihypertensive ability stems its role as natural calcium antagonist promoter vasodilatory mediators, such nitric oxide. magnesium share an inverse relationship, elevated levels have been shown protective effects against plaque formation well antiarrhythmic effects, all which allow for healthier aging. The purpose this literature review investigate the platelet-activating in pathophysiology hypertension, atherosclerosis, cardiovascular disease, Since biomolecule underexplored, further research studies warranted order navigate putative signaling pathways involved cardioprotective dietary anti-PAF agent.